Biopharm Levo Mechanism of Action

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Warnings Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Caution For Usage Storage Patient Counseling Information MIMS Class ATC Classification Thai FDA Category Presentation/Packing Local Product Insert

Full Prescribing Info

Action

Pharmacology: Pharmacodynamics: Levofloxacin is the L-isomer of the racemate, ofloxacin, a quinolone antimicrobial agent. The antibacterial activity of ofloxacin resides primarily in the L-isomer. The mechanism of action oflevofloxacin and other fluoroquinolone antimicrobials involves inhibition of bacterial topoisomerase IV and DNA gyrase (both of which are type II topoisomerases), enzymes required for DNA replication, transcription, repair and recombination.
Pharmacokinetics: Absorption: Rapid and complete.
Distribution: V_d74-112 L.
Protein binding: 24% to 38%.
Metabolism: Minimally hepatic.
Bioavailability: 99%.
Half-life elimination: 6-8 hours.
Excretion: Urine (87% as unchanged drug, <5% as metabolites) and Feces (<4%).
Toxicology: Preclinical Safety Data: Acute toxicity data: Rat i.v. 423 mg/kg (♂), 395 mg/kg (♀) Dog i.v. 200 mg/kg (♀).
Chronic toxicity data: Beagle i.v. 3 mg/kg/day 4 weeks.

Biopharm Levo Mechanism of Action

levofloxacin

Manufacturer:

Ildong

Distributor:

Biopharm